Technical Meeting:

Accelerating HPV-related Cancer Elimination and HPV Faster

Antwerp 2024

 

Preliminary Meeting Objectives
  • Key Considerations for accelerating elimination of HPV-related cancer strategies:
  • Analyze the current status of WHO Elimination Goals on a global scale and identify opportunities for acceleration of cervical cancer prevention.
  • Present and discuss strategies to accomplish the goal of acceleration of prevention of cancer caused by HPV, such as HPV FASTER and HPV EVEN FASTER.
  • Identify research methodologies to gather evidence on HPV transmission prevention.
  • Feasibility and cost-effectiveness of cancer prevention acceleration strategies
  • Identify essential factors for countries to consider when adopting cervical cancer accelerated elimination, such as cervical cancer screening coverage, screening platforms, vaccination strategies, and epidemiological data for program customization.
  • Define the optimal maximum age for HPV vaccination and related determinants.
  • Explore the utility of modeling studies in refining and advancing these programs.
  • Analyze the influence of vaccine pricing, dosing, and scheduling on cervical cancer accelerated elimination cost-effectiveness, and propose optimization strategies.
  • Evaluation of accelerated cervical cancer elimination strategies
  • Discuss methods to measure both the goal indicators and cost-effectiveness of HPV FASTER initiatives.
  • Deliberate on specific resource-stratified requirements at the country level for implementation of HPV FASTER.
  • Assessment of HPV FASTER Implementation Across Countries
  • Review the needs assessment procedures that led to the adoption of HPV FASTER in different countries, highlighting lessons learned and best practices.
  • Understand the next steps and future research needs/gaps for these strategies

DAY 1 – Thursday, June 6, 2024

SESSION 1: WELCOME AND INTRODUCTION

Alex Vorsters (University of Antwerp) (Video, Pdf)

SESSION 2: UPDATE ON WHO’S CERVICAL CANCER ELIMINATION GOALS
Chairs: Paolo Bonanni (University of Florence) & Narendra K. Arora (The INCLEN Trust)​

  • WHO Cervical Cancer Elimination Goals – increasing access to cervical cancer screening and treatment
    Maribel Almonte (IARC) (Video, Pdf)
  • Global overview on the status of cervical cancer screening
    Marc Arbyn (Sciensano) (Video)
  • Current landscape of HPV vaccination and the way towards elimination
    Paul Bloem (WHO) (Video, Pdf)
  • Q&A (Video)

SESSION 3: INSIGHTS INTO HPV NATURAL INFECTION AND TRANSMISSION DYNAMICS 
Chairs: Mario Poljak (University of Ljubljana) & Susanne Krüger Kjær (Danish Cancer Institute)

  • Research insights on latency, immune control and subclinical infection.
    John Doorbar (UC) – Basic science (Video, Pdf)
    Patti Gravitt (NIH) – Clinical evidence (Video, Pdf)
  • Q&A (Video)
  • Understanding local HPV-related immunity using First Void Urine (FVU)
    Laura Téblick (UA) (Video, Pdf)
  • HPV vaccination on HPV-positive women: Using functional in-vitro models to understand HPV infectivity and transmission
    Miguel Ángel Pavón (ICO) (Video, Pdf)
  • Investigations to understand HPV transmission among heterosexual couples: TRAP-HPV trial & HITCH cohort study
    Eduardo Franco (McGill University) (Video, Pdf)
  • Adjuvant effect of HPV vaccine on recurrent respiratory papillomatosis
    Shazia Peer (University of Cape Town) (Video)
  • Q&A and Discussion
    – What gaps exist in our understanding of HPV infection, and what additional information is necessary to fill these gaps?
    – How are we monitoring HPV infections?
    (Video)

SESSION 4: IMPLEMENTATION OF HPV FASTER: LESSONS LEARNED, FEASIBILITY AND COST-EFFECTIVENESS
Chairs: Rolando Herrero (ACIB) & Sharon Hanley (University of Aberdeen)

  • An overview on HPV Faster: Understanding the concept of HPV Faster and the way forward
    Xavier Bosch (ICO) (Video)
  • Targeting FASTER to reduce HPV reproductive rates: “Even Faster”
    Joakim Dillner (Karolinska Institutet) (Video, Pdf)
  • HPV Faster implementation in Mexico: A pilot study
    Jorge Salmerón – MoH, Mexico (Video, Pdf)
  • Enhancing HPV elimination efforts in Israel
    Jacob Bornstein (ISSSTI, Israel) (Video, Pdf)
  • Accelerating HPV related cancer elimination: Bhutan’s Cervical Cancer Elimination Flagship program (as an example from LMIC)
    Pempa Pempa (MoH, Bhutan) (Video, Pdf)
  • Q&A (Video)

SESSION 5: PANEL/ROUND TABLE DISCUSSION: HPV FASTER FEASIBILITY AND EQUITY
Chairs: Aimee Kreimer (NIH) & Kate Cuschieri (University of Edinburgh)

  • Research and implementation opportunities to accelerate cervical cancer prevention in Costa Rica
    Aimee Kreimer (NIH) (Video, Pdf)
  • Topic: HPV FASTER – Feasibility & Equity
    – Can current evidence support a nested HPV vaccination program/campaign in cervical cancer screening?
    – Context-specific implementation feasibility considerations: vaccine dosage, supply prioritization, cervical screening platform, structure, etc.
    – Should HPV FASTER be deployed through campaigns or integrated into routine healthcare settings for optimal impact?
    – How can HPV FASTER be implemented to promote equity in eliminating cervical cancer and other HPV-related diseases? What are the equity considerations and risks?Panelists: Joakim Dillner (online), Marc Arbyn, Iacopo Baussano, Maribel Almonte, Ruanne Barnabas (online), Marc Bardou
    (Video)

DAY 2 – Friday, June 7, 2024

DAY 2: WELCOME SESSION
Chairs: Alex Vorsters (University of Antwerp)

Welcome and Brief overview of day 1 discussions
Alex Vorsters (Video)

SESSION 6: ACCELERATING ELIMINATION OF CERVICAL CANCER: TRANSFORMING CURRENT INSIGHTS INTO EQUITABLE STRATEGIES FOR GLOBAL SUCCESS
Chairs: Dorothy Machalek (Kirby Institute) & Eduardo Franco (McGill University)

  • Rethinking Cervical Cancer Elimination Goal Indicators: From ASR to Lifetime risks
    Eduardo Franco (McGill University) (Video, Pdf)
  • Effective HPV vaccine dose reallocation given recent single dose recommendation & increased supply and manufacturers
    Irene Man (IARC) (Video, Pdf)
  • Optimal HPV vaccination strategies in LMICS to reach cervical cancer elimination
    Marc Brisson (Université Laval) (Video)
  • Q&A (Video)
  • Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes
    Marc Brisson (Université Laval) (Video)
  • Impact of catch-up human papillomavirus vaccination on cervical cancer incidence in Kenya: A mathematical modelling evaluation of HPV vaccination strategies in the context of moderate HIV prevalence
    Ruanne Barnabas – pre-recorded (Harvard University) (Video, Pdf)
  • Q&A (Video)

SESSION 7: HPV FASTER STRATEGY FOR AT-RISK POPULATION AND STRATEGIES TO MOVE FORWARD
Chairs: Marc Steben (ISTTDR) & Armando Baena (IARC)

  • Considerations of HPV Faster strategy in at-risk populations
    Marc Bardou (INSERM) (Video, Pdf)
  • Overview on IARC’s projects targeting at-risk population
    Iacopo Baussano (IARC) (Video, Pdf)
  • Q&A (Video)

SESSION 8: BREAKOUT GROUPS
Chairs: TBD

  • Breakout groups
    Breakout Group 1:
    Chairs:
    Breakout Group 2:
    Chairs:
    Breakout Group 3:
    Chairs:
  • Plenary Feedback
    (Video)

SESSION 9: CONCLUSION
Chairs: TBD

  • Summary
    Marc Baay (Video, Pdf)
  • Concluding remarks
    Alex Vorsters (Video)